Sudden cardiac arrest is a serious medical condition claiming numerous lives across the globe. The fact that in most cases the victim succumbs to death within an hour of the onset of symptoms itself indicates the dreadful nature of the disease. The comparative study of values obtained through the analysis of diseased and normal subjects clearly shows that the value is always less for the normal subjects. This difference is statistically significant. The analysis leads to formulation of biomarkers which may be used to detect abnormalities of the human heart sufficiently ahead of the time before they turn fatal.

Objective: The objective of this work is to formulate biomarkers based on visibility graph technique for early detection of sudden cardiac arrests.

Background: Sudden cardiac arrest is a serious medical condition claiming numerous lives across the globe. The fact that in most cases the victim succumbs to death within an hour of the onset of symptoms itself indicates the dreadful nature of the disease. This very fact has prompted us to analyze an ECG waveform using a chaos based non-linear technique viz. visibility graph technique.

Method: The visibility graph algorithm has been used to convert the ECG time series data into visibility graphs and then calculate power of scale-freeness in visibility graph (PSVG) values at an interval of one minute across the time series. Subsequently, comparative analysis of PSVG values has been carried out between diseased and normal subjects.

Results: The comparative study of PSVG values of diseased and normal subjects clearly shows that for diseased subjects mean PSVG is always less and this difference is statistically significant. Decrease in PSVG values is an indicator of dysfunction of the heart and the extent of deviation is an indicator of the degree of dysfunction.

Conclusion: The analysis leads to formulation of biomarkers which may be used to detect abnormalities of the human heart sufficiently ahead of the time before it turns out to be fatal.


Authors: Nilanjana P, Anirban Bhaduri, Susmita Bhaduri and Dipak Ghosh
Non-Invasive Alarm Generation for Sudden Cardiac Arrest: A Pilot Study with Visibility Graph Technique. Transl Biomed. 2016, 7:3. (Probable Impact Factor: 1.12)
DOI: 10.21767/2172-0479.100079
Transl Biomed. 2016, 7:3
Status :Published
Area : Biomedical Data analysis